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[DOI] [PMC free article] [PubMed] [Google Scholar] 43.Marletta A.S., Massarotti A., Orsomando G., Magni G., Rizzi M., Garavaglia S

Treat it as an adjacent experimental research compound whose relevance to people is unproven

Many patients with ongoing issues like joint pain or inflammation experience long-term relief with regular peptide therapy

Subcutaneous injection is the only route with published pharmacokinetic data (rodent studies), making it the better-characterized delivery method

The protein is proteolytically cleaved to monomers that facilitate the aggregation of keratin intermediate microfibrils and collapse of the corneocyte cytoplasm (Steinert et al., 1981), after which the protein is further degraded to amino acids that aid in maintaining moisture in the stratum corneum (Harding and Scott, 1983