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NNMT inhibition with 5-Amino-1MQ reduced white adipose tissue mass by ~35% in diet-induced obese mouse models without suppressing food intake, suggesting energy expenditure modulation

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In the withdrawal trial, participants switched to placebo regained about 14% over the following year. Tapering, protein at roughly 0.7 g per pound, resistance training, and follow-up reduce the risk, but no post-stop protocol guarantees maintenance

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