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One user reported: "I have used GHK-cu injectable and topical and found no effect on E2 or DHT." The tradeoff is that GHK-Cu doesn't address the underlying hormonal cause of androgenetic alopecia

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The phenotypic expression and the consequences of the mutations depend on the remaining amount of wt-mtDNA, the functionality of the mitochondria, the location in the cell, and their capacity to produce ATP in relation to the demand of the tissue

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But regulations change frequently, and the specific rules can be nuanced