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Similarly, dual-modified nanocomplexes show IC values of 5.54 g/mL in LO2 cells and 3.95 g/mL in HepG2 cells, demonstrating both cell-type specificity and relatively low toxicity [236].These comparative data underscore the necessity of size, surface charge, and chemical composition optimization in nanomaterial design

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miR-99a expressing OEC-M1 cells showed decreased migration and invasion activities and these effects were rescued by ectopic expression of IGF-1R indicating that miR-99a has a role as a tumor suppressor in OSCC via IGF-1R regulation

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