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110 Mechanistic studies have shown that combination therapy induces increased ROS and lipid peroxides and depletion of GSH, and downregulates ferroptosis inhibitory proteins, including FTH1, SLC7A11, GPX4, and FPN, 110 suggesting that -elemene is a novel inducer of ferroptosis

Discussion In the treatment of dermatological diseases, liposomes have been widely utilized for topical drug delivery due to their lipid-like structure and excellent biocompatibility

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PMID 10611280