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First described back in the 1950s, acne erupts in about one in ten people within days or even hours of getting an injection of vitamin B12, which then disappears rapidly when injection treatment is discontinued. At the time, we had no idea what the mechanism might be, and the problem remained unsolved until just a few years ago when we finally figured it out: Vitamin B12 modulates the gene expression of the skin bacteria that cause acne

doi: 10.1186/s12906-020-03152-7 523 LiuHHuaYLuoHShenZTaoXZhuX

Genetic factors may also play a role

Ouwendijk et al., 2021)

Some environmental contaminants, such as pesticides, have also been found in royal jelly and could lead to allergic reactions ( While using royal jelly is likely safe for most people, serious adverse reactions have occasionally been reported