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10.1152/ajpgi.00183.2002 Am J Physiol Gastrointest Liver Physiol

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The enzymes regulating the activation/deactivation of these THs are the deiodinases (DIOs), which are selenoproteins involved in THs fine-tuning of the intracellular concentration and the biological activity of THs

Peptides are often biologically active as signaling molecules without requiring full protein folding