Joseph Rizzo, senior author of the July 2024 study that found an association between semaglutide and NAION, called the condition, in effect, a stroke of the optic nerve. Rizzo is the director of neuro-ophthalmology at Mass Eye and Ear in Boston
A retrospective study of knee pain
Across these studies, oral semaglutide led to clear weight reduction
CANA also decreased total HHF events overall (mean event ratio 0.63, 95% CI 0.54, 0.73) and across eGFR subgroups (interaction P = 0.51)
This supports more balanced availability throughout the body
As with any powerful therapy, there are questions we still need to answer: how these drugs behave over decades, how to protect lean mass at scale, how to dose safely in metabolically healthy individuals, how to separate genuine medical use from cosmetic hype, and how to ensure patients are not starved of protein or muscle