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The observed reduction in NNT achieved by the inclusion of additional endpoints beyond the primary endpoint speaks to the limitations of a restricted definition of benefit
Clinical trials show that gradual dose escalation reduces nausea and improves tolerability while achieving sustainable weight reduction
18 DPP-4 inhibitors, as mentioned above, can be used safely in patients with renal impairment
J Glob Optim 65(2):283307 The CGAL Project (2024) CGAL User and Reference Manual
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