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J.CurhanG.et al (2024)

One last thing to note is that Transparent Labs doesnt use any artificial sweeteners or flavors, while 1st Phorm does

Four datapoints were excluded for one cage in vehicle group due to food spillage on day 11-14

The primary preclinical evidence comes from mouse studies showing reduced body weight and adipose mass in diet-induced obese mice (2018), improved grip strength in aged mice (2024), and beneficial microbiome changes when combined with caloric restriction (2022)