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Even phentermine and semaglutide combinations raise more flags

GLP-1s are also not appropriate for : Individuals who are underweight or undernourished Those at risk for sarcopenia (muscle loss) People with low muscle mass or nutritional deficiencies Adults over 65 with osteopenia, osteoporosis, or a recent history of fractures In these cases, reduced appetite and unintended weight loss can accelerate muscle and bone loss, making close medical supervision essential

The relative contribution of each mechanism likely varies among individuals and may depend on baseline cardiovascular status, concurrent medications, and the specific GLP-1 receptor agonist used

Childhood and adolescent obesity in the United States: a public health concern

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For restaurant chains and snacking giants, higher adoption of weight loss and diabetes treatments poses a threat to their sales or an opportunity