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Aging is another factor

10.3389/FONC.2023.1145082 19 ChengS

In this interaction, several other associated proteins such as IGFBP 1 to 6, insulin (INS), insulin to its receptor (INSR), and vascular endothelial growth factor A (VEGFA) were found to interact with each other through IGF-1 and IGF1R

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Juei-Tang Cheng Joshua Reed, Stephen C Bain, Venkateswarlu Kanamarlapudi Institute of Life Science, Medical School, Swansea University, Swansea, SA2 8PP, UK Correspondence: Venkateswarlu Kanamarlapudi, Institute of Life Science, Medical School, Swansea University, Swansea, SA2 8PP, UK, Tel +44 1792 295012, Fax +44 1792 602148, Email [email protected] Abstract: In healthy humans, the complex biochemical interplay between organs maintains metabolic homeostasis and pathological alterations in this process result in impaired metabolic homeostasis, causing metabolic diseases such as diabetes and obesity, which are major global healthcare burdens