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In many of these studies, drug doses selected for evaluation are not necessarily related to clinical studies and plasma drug levels (a useful measure to compare whether preclinical studies have direct clinical relevance) are not reported and thus cannot be compared to those achievable in humans

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Chen Y, Zhang J, Tian Y, Xu X, Wang B, Huang Z, et al

It also upregulates the transcription of IL-1, IL-18, and TNF-, forming positive feedback

10.1242/jcs.113662 J

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