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Targeting HDACs with HDACi might have potential for treatment of neurological disorders such as Huntington's disease, Alzheimer's disease, amyotrophic lateral sclerosis, seizure disorders, spinal muscular atrophy, Rett syndrome, stroke, Fragile X syndrome, and Rubinstein-Taybi syndrome (Chuang et al., 2009)
This increases the concentration of malonyl-CoA, the first intermediate in fatty acid synthesis, leading to the inhibition of carnitine acyltransferase 1, thereby preventing fatty acid entry into the mitochondrial matrix for oxidation
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