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The main objective of this article is to outline the mechanism of depression in the context of GD, so as to provide references for future studies on the prevention and treatment of GD emotional complications

The data regarding electrophoretic mobility shift assays, nonenzymatic reaction between roGFP2 WT (SH) 2 and GSSG, thiol-specificity of the PfGrx-catalyzed reduction of roGFP2 WT (S 2 ), and rate constants at variable GSH concentrations are provided in the Supplementary Information

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