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The activation of IER3 in the mucosa downregulates Nrf2 through the PI3K/Akt pathway, leading to decreased ROS production and apoptosis in a colitis model, which keeps Nrf2 levels low in IBD (94)

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Beyond gastrointestinal effects, clinical data and class-level evidence from licensed incretin agents (semaglutide, tirzepatide) have flagged concerns regarding: Heart rate elevation: Increases in resting heart rate are a recognised class effect of GLP-1 receptor agonists, documented in the SmPCs for semaglutide (Wegovy) and tirzepatide (Mounjaro)