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Developed by Novo Nordisk in the late 1990s, ipamorelin stimulates growth hormone (GH) release from somatotroph cells in the anterior pituitary gland through direct receptor activation, triggering the Gq/11-phospholipase C signalling cascade that leads to calcium-mediated exocytosis of GH-containing secretory granules

Young MA, Wald JA, Matthews JE, et al

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