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This improves flow without meaningfully impacting stability since the exposure time is minimal

ROS: Reactive Oxygen Species

In some embodiments, the otoprotectant is a compound of Formula (VIII) having the structure of Formula (VIIIa): In some embodiments, the otoprotectant is a compound of Formula (IX): wherein: R 1 is C 6 -C 10 aryl or C 3 -C 9 heteroaryl, wherein C 6 -C 10 aryl and C 3 -C 9 heteroaryl are optionally substituted with one or more R 4

It is also written FOX04-DRI and sold by some vendors as Proxofim

However, T315I-Bcr-Abl-32D cells are less vulnerable to JMF4073