The secretion of GH in both fish and mammals follows a pulsatile, circadian pattern, with relatively higher release during the dark phase ( Main Hormonal Regulators of SomatotrophsGHRH and Somatostatin Two brain (hypothalamus)derived modulating factors, the stimulator GHRH and the inhibitor somatostatin ( Figure 1 ) ( Like GHRH, somatostatin is also a hypothalamic peptide, but inhibits GH secretion in vivo and in vitro in rats ( in vitro stimulatory effects of TRH in amphibians and reptiles ( in vitro , while the same dose and duration failed to modulate GH in chicken and rat pituitary cultures ( In addition to GHRH and somatostatin, there are several additional regulators of GH
[PubMed: 1310712] 435
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Cycling prevents receptor desensitization, the process by which sustained stimulation causes receptors to internalize and reduce their response
