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They are all indicated for individuals with a body mass index (BMI) of 30 kg/m2 or BMI 27 kg/m2 with at least one adiposity-related disease

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The Diabetes Control and Complications Trial research group previously observed that early worsening of diabetic retinopathy can occur with intensive glycemic control, though effective glycemic control ultimately lowers retinopathy risk over the long-term

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unlike the red cell transporter, some of these are insulin-dependent (eg, in muscle and adipose tissue)