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18 Estrogen-only therapy (for women without a uterus) was associated with lower breast cancer incidence and mortality Estrogen plus progestin therapy showed a slight increase in breast cancer incidence, but no increase in breast cancer mortality Additional reviews examining hormone therapy in women with a history of breast cancer found no increase in breast cancer mortality , with only one study showing increased local recurrence, not distant spread or death

PMID: 47 AlfeelAHusseinSYousifTEBabkerAAltoumAAMohamedAet al

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however, their clinical efficacy is yet to be determined

doi: 10.1016/S0140-6736(16)31679-8 52