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treatment of blood cells with lead resulted in ROS-independent eryptosis without any increase in ROS, but with an increase in Ca 2+ level and caspase-3 activity

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J Pharmacol Exp Ther 311:99108 Clancy RM, Levartovsky D, Leszczynska-Piziak J, Yegudin J, Abramson SB (1994) Nitric oxide reacts with intracellular glutathione and activates the hexose monophosphate shunt in human neutrophils: evidence for S-nitrosoglutathione as a bioactive intermediary

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doi: 10.1016/j.freeradbiomed.2018.02.009 112 WillisBCLieblerJMLuby-PhelpsKNicholsonAGCrandallEDDu BoisRMet al