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Theoretically, GLP-1RAs can worsen liver fibrosis by stimulating M2 cell differentiation

These are protein-based biological products that can degrade when exposed to temperatures outside their recommended storage range

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Your specialist weight management service will arrange reviews according to local protocols, with a key assessment after 12 weeks at the 3.0 mg dose to determine whether treatment should continue (typically requiring at least 5% weight loss from baseline, per NICE TA664)

Reducing fiber dose on injection day, as discussed in the timing section, can prevent compounding side effects