Reductions were sustained over the study period
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Berberine regulates the mRNA levels of glucose-regulated protein 78 (GRP78), CCAAT/enhancer binding protein (C/EBP) -homologous protein (CHOP), procaspase-3/9/12 in Alzheimers disease rats hippocampus, which involve in the endoplasmic reticulum stress pathway (Xuan et al., 2020)
The production process is regulated by enzymes such as tyrosinase, which plays a central role in converting the amino acid tyrosine into melanin
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