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Collectively, these data indicate that the enhanced glycaemic effects of GLP-1GIPLani originate from its ability to improve insulin sensitivity through decreased inflammation in key glucometabolic tissues, leading to enhanced suppression of endogenous glucose production and increased glucose uptake into these tissues

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This is a high-risk population, and historically weve had limited data to guide treatment decisions, said Amy Sheer, M.D., M.P.H., an associate professor of medicine and director of the Obesity Medicine Fellowship program at the University of Florida in Gainesville, Florida

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Protein concentration in the supernatant was determined using the bicinchoninic acid assay kit (Pierce, Rockford, IL, USA)

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