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Further analysis suggested that the peptide may have increased the ratio of Bcl-2/Bax, and potentially decreased cleaved caspase-3 and PARP levels, two markers of cell death

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Quercetin, a key active constituent in the Jiangya Tongluo decoction (JYTL) for treating HTN, works in concert with tanshinone IIA and adenosine to exert renoprotective and anti-fibrotic effects to alleviate pathological changes including mitochondrial swelling, glomerular ischemia and sclerosis, interstitial fibrosis, inflammatory cell infiltration, and compensatory dilation of renal tubules in HTN mice