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Additionally, some mechanistic inferences are based on observational data of metabolite levels or single-gene regulation, lacking causal validation via interventional experiments

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50 Excess ROS lead to oxidative stress, which can damage DNA, proteins, and cell membranes

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Paracetamol or acetaminophen ingestion can result in a variety of toxic syndromes predominantly related to alterations of glutathione metabolism and/or depletion of glutathione stores