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Research Models and What a Convincing Trial Would Require Understanding why the answer to the title remains indicative, not proven is easier once you see how the compound has been studied and what a definitive study would demand

The experiment started when mice were 4 months of age and ended when they were 7 months of age for a treatment period of three months (12 weeks)

TABLE 4

We monitored levels of antibodies against LCMV Cl13 glycoprotein 1 (Gp1) by ELISA at various time points after infection and observed that both early (IgM) and late (IgG) responses were undetectable in serum of infected mutant mice, in contrast to infected controls (Fig

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Puchades, C