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5557 Moreover, Chinese herbal formulas like Tong-Xie-Yao-Fang and Tong-Xie-Ning , composed of Atractylodis macrocephalae , Paeoniae alba , Citrus reticulata , and Saposhnikoviae , have shown significant efficacy in randomized controlled trials (RCTs) for treating diarrhea-predominant IBS, reducing pain frequency and improving stool consistency

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While the precise mechanisms linking these metabolic alterations to fibrotic remodeling remain to be fully elucidated, current studies strongly support amino acid metabolism as a central regulatory axis in fibrosis initiation and progression