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Association of human whole blood NAD + contents with aging

Given that both of these studies were in patients with OA of the knee (a load-bearing joint), it is likely that a significant proportion of the efficacy observed was due to the significant loss of body weight, reducing pathological joint loading

Thats not healthy weight loss, and its the wrong way to address this metabolic disease

Additionally, elevated cortisol impairs glucose tolerance and frequently causes secondary diabetes through increased hepatic glucose production and peripheral insulin resistance

4C), which is consistent with the previous study