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Ghrelin administration in the fed state increased OFC and hippocampus activation similar to fasting (i.e., endogenous ghrelinemia) (Goldstone et al., 2014)
This means compounded GLP-1 sellers will have a few months to take their products (which are far cheaper than their branded counterparts) off the market
Moreover, combination therapies have demonstrated significant advantages, such as Novo Nordisks CagriSema (semaglutide + cagrilintide), which shows superior glycemic control and weight reduction effects compared to semaglutide alone, demonstrating that combination therapy can achieve more than the sum of its parts while reducing side effects
Its approval specifically for chronic weight management distinguishes it from many other GLP-1 based medications primarily indicated for diabetes, thereby carving a niche segment focused on the growing global obesity epidemic