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The HPA axis organs may become desensitized and damaged, leading to a kink in the system and an overproduction of cortisol (Anderson 2008)

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Frontal cortex concentrations increased by 50% from 2016 to 2024, with dementia cases exhibiting higher accumulation than controls (Nihart et al., 2025)

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The units to milligrams conversion depends on your specific reconstitution