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Metabolically healthy obesity

Outcome Meas

doi: 10.1016/j.cmet.2021.12.005 67 KnerrPJMowerySADourosJDPremdjeeBHjllundKRHeYet al

FIGURE 8 The aforementioned abnormalities at the molecular level (downregulation of the Nrf2/HO-1 axis and GPX4) and subcellular structural level (neuronal somata and mitochondrial impairment) were consistent with the GSH metabolism perturbations identified by multi-omics analyses, collectively reflecting oxidative stress-associated damage in the hippocampus during SAE

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It undergoes a conversion in vivo to hydroxylated products that may exert antioxidant activity ( N,N -Diphenyl- p -phenylene diamine (DPPD) is used as an AT in the lubricant and polymer industries