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Saudi J Biol Sci 25(2):349353

Badawy AA, Guillemin G

Start your intake What Clinical Trials Show About GLP-1 and Mood Changes Large randomized controlled trials of semaglutide and tirzepatide have documented mood disturbances in 14% of participants, with depression reported more frequently than in placebo groups

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These retrospective studies, although smaller than the large database studies, enable more detailed analysis by virtue of including nuanced data from retinal imaging and longitudinal follow-up after retinopathy development or progression

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