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While T3 and T4 primarily act on hepatocytes to regulate lipid metabolism, THR expression in HSCs suggests that excessive TH levels may activate these cells, potentially contributing to fibrogenesis in hyperthyroid states ( Growing evidence from clinical and experimental studies has established a significant association between hypothyroidismboth overt and subclinicaland the development and progression of MAFLD in both adult and pediatric populations (33)

Neurotransmitters: the critical modulators regulating gut-brain axis

Phase I-ii clinical trial with autologous bone marrow derived mesenchymal stem cells for the therapy of multiple sclerosis