Specifically, in young animals, all three treatmentslow-dose paraxanthine, high-dose paraxanthine, and caffeineenhanced learning and memory compared to control
While experimental conditions were well controlled and mechanistic pathways clearly demonstrated, randomization and blinding procedures were not fully described, resulting in unclear risk for selection and detection bias under JBI appraisal
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This was evidenced by decreased levels of IL-1, TNF-, and IL-6, and increased levels of IFN- which led to an activated macrophagic response that restricted Mtb replication [70]
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