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Since NNMT activity has been connected to age-related metabolic alterations, researchers have also investigated its potential involvement in healthy aging (4)

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Incretin-based therapies in prediabetes: Current evidence and future perspectives

We observed that the annual eGFR decline in the monotherapy period of SGLT2i or GLP1Ra (2.6 9.9 mL/min/1.73 m 2 /year) was significantly lower after combination therapy (1.2 6.0 mL/min/1.73 m 2 /year) ( p = 0.005)

The study identified key residues and structural features, such as the conformation of extracellular loop 1 (ECL1) in GIPR, that contribute to the differential binding and activation of the receptors