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Evidence base reflects FertilitySmart's editorial summary of the trial literature cited in this article: A indicates multiple RCTs supported by meta-analysis

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402,403,404 By modulating PPAR/TRPC1/TRPC6 expression or inhibiting Notch3 signaling, sildenafil effectively mitigated PASMCs proliferation and HPVR, alleviating right ventricular pressure/hypertrophy

These approaches, from conventional drug combinations to novel immunomodulatory and non-antifungal partnerships, represent a promising advance in antifungal therapeutics

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