Monti and colleagues in Uruguay ran a double-blind crossover of 25 nmol/kg over four nights and found that although several sleep measures moved in the expected direction, none differed significantly from baseline or placebo, and where differences did reach significance for NREM and stage 2 sleep, the same differences already existed at baseline
Guo YJ, Deng GF, Xu XR, Wu S, Li S, Xia EQ , et al
Reserpine as a monoamine-depleting agent that blocks the transport of these neurotransmitters into their vesicles by inhibiting the activity of vesicular monoamine transporter (VMAT) can contribute to an increase in oxidative stress in nerve cells and exhaustion of antioxidant molecules such as GSH
Free radicals are unstable molecules generated by environmental stressors like UV radiation, pollution, and smoking
J Nutr Biochem (2016) 28:10313
And its a very comprehensive process that weve built over the last few years