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Stable health with no contraindications to GLP-1 Goal: sustained weight reduction inside a longevity protocol Ready to commit to 1668 weeks of treatment + lab monitoring NOT A CANDIDATE Clinical exclusions Personal/family history of medullary thyroid carcinoma or MEN-2 Currently pregnant or planning pregnancy Active pancreatitis or severe gastroparesis Your prescriber will review your full medical history at consult MAYBE DEPENDS ON LABS Conditional cases Pre-existing GI conditions Kidney function below threshold (needs additional labs) Currently on another GLP-1 or dual agonist Recent significant weight loss without medication CLINICAL NOTE Eligibility is established at consult

Bottom line GERD and hiatus hernia are not contraindications to GLP-1RAs or tirzepatide

Cohen-Adad J, El Mendili MM, Lehricy S, Pradat PF, Blancho S, Rossignol S, et al

Pathway bias analysis using parameters derived from this cellular model again further supports that, relative to liraglutide, PF-06882961 has minor (3-fold) bias away from internalization (vs

Adding the GIP component improves insulin sensitivity and may help the body tolerate higher doses of the GLP-1 component