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When any component fails, oral supplementation becomes far less effective, potentially requiring massive doses to achieve therapeutic blood levels

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It is generally considered safe to receive B12 injections from a qualified healthcare professional, provided they are administered by a trained individual

Digestive diseases: such diseases as Crohn's or coeliac hamper the absorption of B12 in the ileum

This is particularly important for individuals with gastrointestinal disorders, reduced intrinsic factor, or other malabsorption concerns