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The abnormal accumulation of lipid accumulation in hepatocytes initially exerts a lipid-toxic effect, causing the release of damage-associated molecular patterns (DAMPs) and other stimulated excretions (Kang and Tang 2017)

Vitamin D exerts its influence on the brain through its binding to vitamin D receptors, which are extensively dispersed in the prefrontal cortex, cingulate cortex, and limbic system

& Oster, G

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The Phase 2 readout established the dose-response signal that the Phase 3 program later confirmed at scale