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Similarly, compounds in grapefruit juice (furanocoumarins) inhibit CYP3A4 and raise levels of certain calcium blockers
The PERK inhibitors GSK2606414 and GSK2656157 effectively reversed TMAO-induced upregulation of ICAM-1 in HAECs [152], implicating PERK signaling as a mediator of TMAO-driven atherosclerosis
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