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This early appetite suppression occurs because GLP-1 receptors in the hypothalamus are activated, reducing hunger signals and increasing feelings of fullness

Gradual dose escalation improves gastrointestinal tolerability.78 Acute pancreatitis is a rare but documented adverse event associated with exenatide use, as reported in the FDA Adverse Event Reporting System and observational studies.79 Current guidelines from the American Association of Clinical Endocrinologists recommend cautious use of GLP-1RAs in T2DM patients with a history of pancreatitis80 (See Figures 2 and 3)

Diarrhea can worsen hemorrhoids in several ways: Frequent Bowel Movements When you have diarrhea, you may need to use the bathroom many times a day

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