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Interpretation Normal levels : Reflect balanced bone turnover Elevated levels : Suggest increased bone resorption Low levels : May indicate effective anti-resorptive therapy or low osteoclast activity Because bone turnover varies with age, sex, and menopausal status, results must be compared against reference ranges

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Researchers should establish and document a fixed weekly injection day and approximate time of day for each study subject to facilitate steady-state pharmacokinetic modeling