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Physiology - Endocrinol

David Maron, a cardiologist at Stanford, speculated that the drugs benefits go beyond simple weight loss, possibly by improving overall health and reducing chronic inflammation

Metformin inhibits mitochondrial dysfunction and apoptosis in cardiomyocytes induced by high glucose via upregulating AMPK activity

In fact, weight loss of as little as 5% in people with diabetes can improve cardiometabolic risk factors, and a weight loss of more than 10% can reduce cardiovascular morbidity and mortality, as demonstrated in the LOOKAHEAD study [5]

Smaller, more frequent meals sit better than large ones because the peptide slows gastric emptying

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