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These results support a useful selectivity window for NNMT research, but they were obtained with a limited panel of related enzymes and do not rule out every possible off-target interaction

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LJ: Investigation, Writing review and editing, Funding acquisition, Project administration

Application Areas: Metabolic Disease Research: Obesity, insulin resistance, type 2 diabetes mechanism and drug development Aging and Longevity Research: NAD+ homeostasis, mitochondrial function, regulation of cell aging pathways Neuroscience Research: Exploration of protective effects on neurodegenerative diseases such as Parkinsons disease Sports Science: Enhancing endurance, promoting muscle repair and improving physical performance research