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Zhang, C., Rodriguez, C., Spaulding, J., Aw, T

The inhibitors designed to target one specific isoform may inadvertently affect others, causing unintended interactions or side effects and complicating their therapeutic use

It is possible that unknown interactions exist

2 Metformin inhibited the proliferation of glioma cells via various process 2.1 Ferroptosis The specific mechanism by which metformin induces ferroptosis to inhibit the proliferation of glioma cells has not been fully clarified