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As a selenium-dependent enzyme, GPX4 specifically catalyzes the reduction of phospholipid hydroperoxides by reduced GSH, converting toxic lipid peroxides into non-toxic lipid alcohols to maintain plasma membrane integrity [64, 65]
On the other hand, ERK showed reduced phosphorylation in GNE mutant cells even after IGF-1 treatment suggesting downregulation of the ERK pathway
10.1146/annurev.neuro.31.060407.125631 Annu
As epitalon has been shown to reproduce the effects of epithalamin, we will use that term throughout unless further specificity is required for clarity
Antillon M, Cominelli F, Reynolds TB, et al
10.1158/0008-5472.CAN-11-2663 Cancer Res
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