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For a long time, the manifestation of depressive symptoms has been also associated with the deficits in neurotrophic factor action in the brain [51], especially highlighting the role of diminished brain-derived neurotrophic factor (BDNF) signaling as important for the pathogenesis of this mental disorder [52]

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HERA 48 was performed by seeding HMEC-1-FcRn cells (1.5 10 5 cells/well) to a Costar 48-well TC-Treated Multiple Well Plate (Corning) in complete culture medium (250 L/well) for approximately 2024 h until confluent